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Demand is shaped by Japans focus on purity, bioavailability, and proven physiological efficacy

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Mashaly MM, Hendricks GL 3rd, Kalama MA, Gehad AE, Abbas AO, Patterson PH (2004) Effect of heat stress on production parameters and immune responses of commercial laying hens

Shortening the current cycle and extending the washout is the correct response, not increasing the dose

For maintenance therapy in individuals with dietary deficiency, doses of 50150 micrograms daily are often sufficient and better tolerated

Alternatively, the variation that is typically seen during T LIM tests could explain the null effect, as these protocols require a large difference in performance to reach statistical significance compared to either fixed duration or distance time trials (Currell and Jeukendrup 2008)